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Although it has some limitations, such as the lack of non-parenchymal cells and loss of P450 enzyme activity over time in culture, for an acute model such as APAP-induced cell death, it generally reproduces most aspects of the in vivo pathophysiology [132], [134]

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IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function